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Treatment of fibroblasts from COPD patients with hemin to activate HO-1 results in reduced cellular senescence, improved mitochondrial function, and reduced ROS production [122] Since Nrf2 activates many other antioxidant genes in addition to HO-1, this suggests that activators of Nrf2 and inhibitors of Keap1 might be even more effective against oxidative stress in COPD

74 The enhanced oxidant stress in the mitochondrial matrix is then mainly derived from complex I and, to a lesser degree, from complex III, 71 and the oxidant stress and injury correlate with protein adduct formation in mitochondria

CRC Press, Boca Raton, FL, pp 1530 Brezova V, Valko M, Breza M et al (2003a) Role of radicals and singlet oxygen in photoactivated DNA cleavage by the anticancer drug camptothecin: an electron paramagnetic resonance study

Gut Health and GI Conditions BPC-157 was discovered in gastric juice protein

Le Toan, H.L.-J

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