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Description

Using doseresponse curve-fitting models, the IC 50 value (the concentration that results in 50% inhibition of cell growth) of each radiation dose and abemaciclib was determined (GraphPad Prism software, version 5)

The resulting aspartate serves as an essential precursor for purine and pyrimidine biosynthesis, thereby supporting nucleotide production required for tumor cell proliferation [251, 252]

10.1186/s12885-021-08242-4 182 KhanS

PloS One (2013) 8(12):e83951

Ferroptosis resistance in tumor cells In addition to System X c /GSH/GPX4 axis, an antioxidant system that protect tumor cells from ferroptosis, a number of new mechanisms of ferroptosis resistance have been found in vivo and in vitro studies of drug-resistant solid tumors mentioned above, which are associated with a variety of metabolic enzymes