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[DOI] [PMC free article] [PubMed] [Google Scholar] DSouza RD, Vijayaraghavan S, 2014

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Withaferin A (WA) has been found to not only inhibit the activity of GPX4 in neuroblastoma but also activate heme oxygenase-1 to increase intracellular Fe 3+ concentration, thereby inducing ferroptosis in neuroblastoma [136]

Intermolecular binding between the two fusion proteins reconstitutes the Gal4 DNA-binding domain with the Gal4 activation domain, which leads to the transcriptional activation of a reporter gene (e.g., lacz, HIS3) which is operably linked to a Gal4 binding site

Chlorthalidone treatment results in a 90.1 per cent decrease from predicted rates and both dosages yielded similar results

Nuclear-coded proteins have specific tags that allow them to be imported across the outer membrane