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stated that fluorescence devices for the chairside diagnosis and quantification of WSLs in orthodontic patients perform moderately, and have no greater advantage than the visual diagnostic methods 28

Another study in 2019 indicated that NIN reduced -SMA and Smad3 protein and mRNA levels and blocked oxidative stress, inflammation and the TGF--Smad3 and JNK-Smad3 pathways, thereby carrying out its antifibrotic effects (Hernndez-Aquino et al., 2019)

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DNA diagnosis and newborn screening are very useful in early diagnosis and early therapy which leads to favourable prognosis