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The NADPH generated during this step is a potent reducing agent, serving as a critical factor in various cellular redox reactions

(b) specific inhibitors of GSH biosynthetic enzymes selectively decrease intracellular GSH in tumors

Hepatocyte ballooning was classified as 0 (none), 1 (few), or 2 (many cells/prominent ballooning)

Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes

Due to its biochemical nature, and the low activation energy, they are able to react with biomolecules of all cellular structures, thereby carrying out their chemical and physiological modification

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