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Other host barriers should also be considered as potential targets for prevention including the oral cavity and lung mucosa as these have been identified as sites of pathogenic autoreactive immune responses that contribute to autoimmune disease

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J Cell Biochem 120:68606867 Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA (2019) Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

Half of them did not experience the reaction the second time

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