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Although we could not exclude the influence of different isolation procedures for each organ, along with the glutathione accumulation within TLS, these findings suggest that TLS in the kidney represent a unique microenvironment characterized by a dynamic equilibrium between oxidative stress and glutathione accumulation, which may play a pivotal role in regulating the formation of TLS and its function

Although ergothioneine (ERGO) was first discovered over a hundred years ago in 1909, it has only been in the past few decades that research has uncovered the many health benefits of this fungal antioxidant

Phung N, Pera N, Farrell G, Leclercq I, Hou JY, George J (2009) Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis

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In addition, L-asp can restrain cellular oxidative phosphorylation and thus inhibit the proliferation of AML cells and improve the prognosis of refractory leukemia [16]

Additionally, our clinical model is also applicable towards predicting the long-term prognosis of non-basal ganglia intracerebral hemorrhage