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Although OA pathogenesis is exceedingly complex, recent studies underscore the multifactorial nature of the disease, involving mechanical overload, inflammatory responses, metabolic abnormalities, and cell death ( Cartilage deterioration and subchondral bone remodeling are hallmarks of OA

doi: 10.2174/1872213X12666180221161410 203 SalehiBAta AVAnil KumarNSharopovFRamrez-AlarcnKRuiz-OrtegaAet al

10.1016/j.mad.2016.04.005 Mech

Allergic Reactions: Severe allergic reactions, including anaphylaxis, can be life-threatening

Conclusions and future directions In this review we have emphasized the role of synaptic activity in the remodeling of GABAergic synapse structure and discussed the possible roles of structural plasticity in sensory processing and memory formation