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However, systemic use of HDACis negatively affects the generation of new myelin since histone deacetylation is important for progenitor cell differentiation into myelin-forming oligodendrocytes [96] and is critical for remyelination efficiency in adults [88], as we reviewed previously

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Its likely that the presence of the vitamin improves the rate of absorbance of the MSM, producing more potent effects

Oral, sublingual, and injectable forms absorb differently, affecting how well they work