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However, this compound can also be absorbed by macrophages during the formation of atherosclerotic plaque, with TMAO molecules binding to specific receptors on the surface of the macrophages, which triggers a series of signaling events inside the cell that activate specific pathways that induce the expression of genes involved in cholesterol metabolism, inflammation, and oxidative stress (77, 78)

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This design supports the statement that FSN-induced microbial state has a transferable therapeutic effect.' Rescue (Sufficiency Support for Key Mediators): Adding butyrate supplement group (adding sodium butyrate to drinking water, 200 mmol/L, 21 days) can restore the level of butyric acid in the body and relieve inflammation, and the content of butyric acid is negatively correlated with inflammation markers (Wen et al., 2025)

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125 This concept was eventually broadened to encompass fiber-based probiotics and other substrates that the host bacteria use selectively and provide health advantages