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Up-regulation of iNOS in AML Blasts Creates an Immunosuppressive Microenvironment, Inhibits T-cell Proliferation and Transforms T-cells Towards a Tumor-tolerating Phenotype

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4.4.2 Epigenetic modulators Given that HDAC suppresses gene transcription ( in vitro and in vivo models (Tarale et al., 2018)

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125 In addition, Gln can promote the expression of lymphocyte surface markers such as CD25 and CD71 and increase the production of cytokines such as IFN- and TNF-

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