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FIGURE 1 Exogenous ROS Environmental triggers, such as exposure to cigarette smoke, UV radiation, heavy metal ions, ozone, allergens, drugs or toxins, pollutants, pesticides, or insecticides, may all contribute to the increase of ROS production in cells (Mahajan et al., 2018

FRAP, fluorescence recovery after photobleaching

This impacts the interaction of histones with the negatively charged DNA and triggers DNA unwinding, nuclear expansion and chromatin condensation

Bundock et al., 1996)

The mechanisms are plausible

2,3 HT has an ethnic preponderance, with the white race characterized by a higher incidence than black or Asian, and Pacific Islanders being rarely affected