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doi: 10.1096/fj.05-4678fje

Introduction Reactive oxygen species (ROS) are oxidants produced during intracellular or extracellular aerobic energy metabolism, and enzymatic reactions have attracted extensive attention from researchers since their discovery ( 2 O 2 , , and OH-, and different single entities can be converted into one another through interconversion reactions ( in vivo , including those within the mitochondria ( T cell-mediated immune responses are essential for resisting multiple pathogenic microbial infections and antitumor immune responses ( + T-cell subtypes depend on different energy metabolism methods, T helper 1 (Th1), Th2, and Th17 cells rely on aerobic glycolysis to reduce lipid oxidation

Second, microvascular endothelial cells in both the brain and the retina form bloodneural barriers with surrounding cells, including pericytes and astrocytes 13,14

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