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14 Natives or long-term high-altitude sojourners, who are chronically exposed to altitude hypoxia, may develop several altitude-related illnesses, including polycythemia, systemic hypertension, pulmonary hypertension, congenital heart disease, thromboembolic disease, lung disease, mental deterioration, as well as pregnancy and neonatal problems

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PMID: 30510356

There is a mounting body of evidence indicating a close association between cellular senescence and the underlying pathophysiology of AKI, as they both exhibit a cell cycle arrest at the G2/M phase, heightened oxidative stress, an increase in cyclin-dependent kinase inhibitors, telomere shortening, and an exacerbated in the fibrotic processes