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Some notable examples include: Folate Folate is an essential methyl donor in the one-carbon metabolic pathway and therefore a crucial component of epigenetic regulation (Gurugubelli and Ballambattu, 2024

In MCF-7 cells, it induced apoptosis and blocked cell cycle progression, hence mediating cell death ( in vitro IC 50 concentrations may not directly reflect clinically achievable plasma or tissue levels, and translational interpretation requires pharmacokinetic validation

44,45,54 Omega-3 Fatty Acids: Kiecolt-Glaser et als 12 weeks long placebo-controlled trial in 2011 showed that Omega-3 fatty acid supplements decreased anxiety in the trial participants by 20% over placebo