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The regulation of COX2 expression is complex, involving transcriptional and post-transcriptional mechanisms influenced by cytokines, growth factors, and pro-inflammatory stimuli (225)

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GA was shown to suppress NLRP3 inflammasome activation, decrease caspase-1 cleavage and IL-1secretion, and upregulate Nrf2 expression, thereby mitigating oxidative stress and inflammation 139

doi: 10.1182/blood.2019004770 Summary Keywords acute myeloid leukemia, leukemia stem cells, drug resistance, resistant mechanisms, LSCs remolding, clonal heterogeneity Citation Niu J, Peng D and Liu L (2022) Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells

Potential Role in Cancer Therapy: Oceania Studies show promise in easing chemotherapy-related side effects and enhancing overall patient comfort during cancer treatments (11)

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