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115 for antioxidant Cigarette smoke is a powerful oxidant causing ment (containing nutrients and suggested widespread cell damage and may accelerate athe- ample amounts of vit- doses.) Should contain at least rosclerosis and other degenerative changes in the skin, lungs, and other organs.68 Vitamin E require- amins A, C, E and zinc 100 mg vitamin E and selenium) ments are higher in smokers

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In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different