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Burns 31 (3), 310315

perforatum extracts may possess significant pharmacological activity by targeting various neurotransmission systems involved in depression

FIGURE 10 Oxidative stress, associated with high dose MTX, triggers a systemic inflammatory response where proinflammatory cytokines further contribute to tissue damage (Vanessa Legry et al., 2022), ovariectomized mice (Morsy et al., 2022)

Currently, most of these therapies are still at the cellular and animal levels, and their safety and efficacy on patients have not been conclusively demonstrated

NRF2 activation in microglia during AD upregulates genes with an antioxidant effect, reducing oxidative stress burden, and exerting effects downstream of its elicited antioxidant response that reduce neuroinflammation (Satoh et al., 2008

Frontiers and controversies in the pathobiology of vitiligo: separating the wheat from the chaff