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Synthesis of compound 5 A solution of compound 4 (290 mg, 1 mmol), Cs 2 CO 3 (325 mg, 1 mmol), compound 25 (188 mg, 1 mmol) and DMF (3 mL) was stirred at room temperature for 12 h under an Ar atmosphere

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For yeast expression, all coding sequences were subcloned into an empty p413TEF plasmid 74 using XbaI and XhoI restriction sites (Supplementary Table 5)

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