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Researchers use these systems to measure growth hormone release, receptor activation kinetics, IGF-1 expression, and downstream metabolic pathway activity

Verdegem and C

L., Olsvik, P

Growth hormone plays a role in protein synthesis, which is the building block for muscle tissue

It is intriguing to see that cellular metabolism and immune activation are so tightly entangled and that a fine-grained interplay is essential to achieve a correct function, said Karsten Hiller, Ph.D., a co-author of the current study and a professor at the Braunschweig University of Technology

The failure of this axis directly damages multiple key processes essential for bone regeneration: the dysfunction of HIF-1 will weaken angiogenesis, while the coordinated regulation of metabolic reprogramming and the balance of oxidative stress by BMAL1-HIF-1 are also disrupted