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Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition

Looking forward, AI-guided design stands to accelerate every phase of this pipeline

Semaglutide trials, by contrast, measure weight loss as a primary outcome, track metabolic changes, and monitor safety across thousands of participants over months

R.StoskopfM

All cryo-EM data were collected on a Titan Krios 300 kV microscope (Thermo Fisher Scientific) equipped with a GIF-Quantum energy filter (Gatan) with the slit set to 20 eV and a Gatan K3 Summit direct electron detection camera (Gatan) at Case Western Reserve University