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The C -alkylation of 40 was carried out using K 2 CO 3 in the presence of Bu 4 NHSO 4 as a phase transfer catalyst, leading to the formation of C -alkylated product 42 in 70% yield

Finally, eluted GST protein dialysis was performed overnight against TBS at 4 C

Other Neurodegeneration Diseases and Metformin Sporadic cerebral amyloidosis (CAA) is caused by the deposition of amyloid (A) protein in the blood vessels of the brain

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156 WHO (2018c)

More specifically, regarding the crucial role of CYP2D6 and CYP3A4 in metabolizing clinically used drugs, and the inhibitory effects of berberine on these two CYP450 isoforms, it seems that the most important drug interaction of berberine that should be considered is related to its inhibitory effect on CYP2D6 and CYP3A4