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Elevated histone acetylation was confirmed in an additional cell line and shown to decrease through the depletion of KG or the suppression of KGDDs using knockdown or inhibition of IDH1, glutamine starvation or succinate supplementation (Fig

Heart failure (HF) is currently considered a systemic multi-organ syndrome fundamentally driven by metabolic failure, and carnitines, a crucial metabolite in fatty acid metabolism, transport long-chain fatty acids into myocardial mitochondria to produce energy as a source of ATP generation [1] (Fig

doi:10.1038/s41586-021-04282-9

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This can cause muscle weakness, stunted growth, an enlarged liver, and other dangerous conditions

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