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In an NC/Nga mouse model, topical application of the Vitamin D analogue calcipotriol increased filaggrin expression and reduced transepidermal water loss (TEWL), highlighting its potential in restoring epidermal barrier function in elderly patients with AD [257]

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Indeed, cell-mediated immunity requires that protein antigens be first degraded in the endocytic vesicles of APCs (eg, macrophages, dendritic cells), so that the smaller peptides can be presented on the cell surface by the major histocompatibility complex to activate proliferation of antigen-specific T cells

Peptide amidation extends their lifespan and efficacy