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This inquiry is not just about whether its safe

The inefficient recycling of Se in BAT for the synthesis of selenoproteins, particularly GPX1 and GPX4 which are involved in adaptive thermogenesis, may potentially lead to increased oxidative stress within this tissue, yet is insufficient to curb heat production

Tumour heterogeneity and the ability of tumour cells to rapidly mutate and develop evasion strategies makes the development of non-invasive imaging capabilities to interrogate these hallmarks as biomarkers and monitor them longitudinally and quantitatively particularly important

Limit free radicals Avoid the toxins that need to be contracted by glutathione

Funding This work was supported by the German Research Foundation (DFG) via the SFB/TRR205 (KF, SRB, AE-A, WT), the IRTG-2251/2 (NB, MT, KF, SRB, AE-A, WT), the IRTG-3019/1 (SRB, WT), and the Else Krner Fresenius-Stiftung (WT, 2025_EKES.07)