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The strength of the cough is regulated by the respiratory muscles, and a weakened cough reflex can lead to the development of pneumonia, especially aspiration pneumonia, in older individuals (167)

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Immune cells are scrutinized by co-stimulatory or co-inhibitory receptors, specific immune checkpoint inhibitors (ICIs) and Transforming growth factor- (TGF-), aiming to impede the devastation of tissues due to immoderate or improper immune responses

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