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The last substantive controlled human sleep study appeared in 1992 and was negative

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Dealing With Co-occurring Disorder: Substance Use and Mental Illness It is common for opioid users to experience mental illness, and often, one becomes the cause of another, paving the way for disorders such as: Depressed mood Persistent depressive disorder (dysthymia) Opioid-induced depressive disorder Bipolar disorder Post-traumatic stress disorder Sometimes, people misuse concurrent substances and may experience withdrawal from them, such that withdrawal associated with sedatives, such as benzos, give opioid-like withdrawal symptoms