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demonstrated that robustaflavone, isolated from Selaginella trichoclada, triggered iron-dependent cell death in breast cancer cells by enhancing the expression of voltage-dependent anion channel 2 (VDAC2) and downregulating Nedd4 E3 ubiquitin ligase, resulting in the generation of lipid peroxidation and ROS (Xie et al., 2021)

Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

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doi: 10.1016/j.intimp.2022.108717 40 SayinNCGcerFBalkanli-KaplanPYceMAYardimT