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A 2015 paper shows that the influenza A virus directly activates mast cells, causing the release of cytokines and contributing to the excessive inflammatory response in the lungs.[ref] Animal studies show that this pattern of mast cell activation and excessive response holds true for several flu strains

17-Acetoxyjolkinolide B irreversibly inhibits IkappaB kinase and induces apoptosis of tumor cells

This paper does not evaluate the impact of aggregate levels on immunogenicity, but seeks to create a useful technique to assess aggregate levels