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Life Sci 75:25392549

Exploring phytochemicals for combating antibiotic resistance in microbial pathogens

Smoking and pollution exposure: Smoking and air pollution increase free radical production

Jackman SR, Witard OC, Philp A, Wallis GA, Baar K, Tipton KD

In fact, kynurenic acid is an antagonist of NMDA and all ionotropic glutamate receptors (74, 75)

In Candida infections, host mitochondria exhibit decreased complex I and complex III activity, correlating with reduced ATP levels and impaired phagocytic killing capacity ( Moreover, gliotoxin from Aspergillus fumigatus and candidalysin from Candida albicans synergistically impair mitochondrial ATP production, weakening epithelial barrier integrity and facilitating fungal invasion ( 4.3 Fungal-induced mitochondrial ROS generation and oxidative stress One of the earliest mitochondrial responses to fungal infection is the excessive generation of mtROS