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Description

C., Wang, J., et al

Zybert, P

This represents a significant jump to approximately 0.9 mg, crossing into the range where meaningful metabolic effects begin

For the final clones selected, the mutations generated in the WT MEFs include an out-of-frame 17-base pair deletion starting at the codon encoding T237 and a large out-of-frame 73-base pair deletion starting after the codon encoding G219, both resulting in premature STOP codons