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Activated AKT then phosphorylats downstram targets, leading to the activation of various signaling pathways ( Multiple mechanisms regulate the PI3K/AKT pathway to maintain cellular homeostasis

The neurotoxic effect of manganese is attributed predominantly to the release of proinflammatory cytokines such as interleukin 1-beta (IL-1) and tumor necrosis factor (TNF-) by microglia and astrocytes (Guilarte et al., 2010[171])