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However, the majority of genetic risk loci are located in the non-coding regions of the genome, and each locus has a small individual contribution to the disease phenotype, making precise localization of disease sites and mechanism parsing for AD a huge challenge (Bellenguez et al., 2022

doi.org/10.1016/j.ctrv.2011.01.006

Upon binding of a ligand to a death receptor, Fas-associated death domain protein (FADD) is recruited and the death-inducing signaling complex (DISC) (for FasL/FasR, TRAIL/TRAIL-R1 or TRAIL-R2) or complex II (in the case of TNF/TNF-R1) is formed

Similarly, the phase IIa PBT2 trial demonstrated acceptable safety and modest biomarker modulation without significant clinical efficacy (Ayton et al., 2025)

Metabolite extraction of the area surrounding cerebral infarction in mice Tissue metabolites were extracted with some modifications of a previously described method [39]

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