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Drugs with similar barrier promoting properties may, therefore, be a useful strategy to improve the integrity of the intestinal epithelium and limit the development of gut-associated and extraintestinal inflammatory diseases (Smyth 2017)

In biology, too much of a good thing can lead to hormesis

However, these variants did not affect the DNA repair activity of APE1, and they do not contribute to the risk of developing sALS (Hayward et al., 1999

10.1126/science.aaw6421 Science 45 GuoR.GewurzB

Given the low therapeutic doses (0.10.5 mg/kg), rapid onset of action, sustained efficacy, and the feasibility of repeated administration without triggering hepatotoxicity, inflammation, or an immune response, hMUT mRNA-based therapy represents a versatile and promising option for MMA treatment [296]

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