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Still, it is a pharmacodynamically expected consequence of glucagon agonism and represents a meaningful differentiator from tirzepatide

(2021) Bilirubin as a metabolic hormone: the physiological relevance of low levels

The metabolic crosstalk between various cell types in the TME, combined with epigenetic regulation, creates a complex metabolic environment that promotes tumor growth, metastasis, and resistance to treatment[25, 26]