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The BBB is characterised by a unique tight endothelial cell layer that covers capillary blood vessels in the CNS

In fact, most of the patients with TDP-43 pathology do not have mutations in their TARDP gene, and yet have protein accumulations containing phosphorylated TDP-43 13 , and mostly ubiquitinated protein aggregates 10,14,15

10.1016/j.imbio.2015.01.002 [DOI] [PubMed] [Google Scholar] 124.Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, et al

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Adapting Koch's postulates

However, unlike studies in animal models, clinical trials have focused more heavily on the anti-colitis action of curcumin and have not given as much attention to its effects on redox and/or anti-inflammatory biochemical markers