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For example, AtWRKY12 combines with the W-box of the GSH1 promoter to directly target GSH1 , inhibit the expression of GSH1 , and indirectly inhibit the expression of genes related to PC synthesis ( AtWRKY13 activates DCD expression and increases the production of H 2 S by directly binding to the DCD promoter (Zhang et al., 2020)

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While glutathione is generally considered safe, some people may experience side effects such as gastrointestinal upset, especially with high doses

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Lavoie S, Murray MM, Deppen P, Knyazeva MG, Berk M, Boulat O, Bovet P, Bush AI, Conus P, Copolov D, Fornari E, Meuli R, Solida A, Vianin P, Cunod M, Buclin T, Do KQ:Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients

The area under the curve of GTT or ITT was analyzed by GraphPad Prism