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Because selenide is highly reactive, it has long been hypothesized that specific molecular carriers exist to transport selenium in a stabilized form within cells [187]

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Nat Chem Biol 11(7):504510

Endothelial and stromal involvement Endothelial cells exposed to IR upregulate adhesion molecules (Intercellular Adhesion Molecule 1 (ICAM-1), Vascular Cell Adhesion Molecule 1 (VCAM-1), E-selectin), enhancing leukocyte recruitment

This knowledge gap has markedly impeded the identification and translation of precision therapeutic targets, thereby constituting the primary motivation for the present review