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An antisense oligonucleotide selective inhibitor of apoCIII has been developed that lowers serum apoCIII and triglycerides in mice, non-human primates, and humans and is currently in a phase 2 clinical trial (653)

Nat Rev Immunol (2013) 13:34961.10.1038/nri3423 9 SchieberMChandelNS

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[DOI] [PubMed] [Google Scholar] 97.Reuter S.E., Faull R.J., Evans A.M

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For an exploration of sub-threshold dosing approaches, our microdosing tirzepatide chart covers the calculations for ultra-low doses