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A process for the preparation of reduced glutathione, which comprises dissolving or suspending in water the reduced glutathione in amorphous spherical form of claims 1 -6 at concentrations higher than 700 g/l, preferably from 700 to 1000 g/l, and more preferably from 800 to 1000 g/l, and subsequent isolation thereof in crystalline form

Such a reaction is possible due to the relatively high concentration of glutathione in cells (up to 5 mM in the liver )

Hepatology 55 , 11031111, (2012)

In patients with COPD, activation and degranulation of neutrophils result in the release of activated NSPs, primarily NE, PR3, and CatG (54), disrupting the normal balance between proteases and antiproteases (53)

Schepers, E

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