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Single-cell RNA sequencing analysis of diabetic nephropathy kidney samples indicates that in regulatory T cells, lactate promotes interaction between the membrane-associated spike protein Moxin and TGF- receptor I by lactylating lysine 72

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This activation of hypoxia-inducible factors considered associations with crosstalk between hypoxia and altered mitochondrial metabolism, which plays an important role in the development of hypoxic pulmonary hypertension

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