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Detoxification is a chain of events - the liver cleanses the system by changing the chemical nature of many toxins, and the kidneys filter toxins out of the blood into the urine

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Untargeted metabolomics enables wide identification of metabolites in a sample but does not always enable elucidation of the chemical structure 139

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12 15] 4 Case Reports/Case Series [16 19] 1 Prospective Trial [20] Dexemedetomidine does not protect against withdrawal seizures and should not be used as monotherapy Ketamine 1 Retrospective Review [21] Clinical Bottom Line Phenobarbital, propofol, and dexmedetomidine have been shown to reduce benzodiazepine requirements in AWS Nothing has proven to shorten AWS duration or ICU LOS Dexmedetomidine does not protect against withdrawal seizures and should not be used as monotherapy References: Rosenson J et al