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This mechanism also acts as a vital "on/off" switch for cellular signaling, modulating enzyme activity and controlling how DNA binds to transcription factors during an immune response

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Figure 1 Furthermore, SAM serves as a methyl donor, methylating DNA and proteins, including histones (Zade et al., 2023), which in turn influences epigenetic regulation, and gene expression ( Figure 1 )

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This roughly represents a doubling of the absolute and relative number of deaths (1.4 million deaths from ASCVD, 11% of all deaths) compared to 1990 (Zhao et al., 2019)

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