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Critically, SV2A correlated with MRS dACC glutamate content (r = 0.55) in healthy controls and in patients in keeping with the predominance of glutamate synapses in cortex and suggesting that MRS glutamate is partly reflective of the presynaptic glutamate pool

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glucuronic acid, glutathione, etc increases water solubility and renal elimination Basic Features: Highly water-soluble drugs excrete unchanged