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Kern and Jones have summarized the important role of Purkinje cell abnormalities in autism, especially the susceptibility of these cells to oxidative stress during GSH depletion

Brought on by the suppression of POLG expression and the overexpression of TFAM, the findings indicate that the overall toxicity was partially linked to the reduction in mtDNAcn

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These studies have correlated symptom burden with significantly increased oxidative stress (Hyman 2010)

Topical administration refers to the application of a pharmaceutical agent to the external surface of the skin or the mucous membranes (including the surface membranes of the nose, lungs and mouth (in which case it may also be a form of oral administration, such that the agent crosses the external surface of the skin or mucous membrane and enters the underlying tissues