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Preclinical models evaluate combined intracellular cAMP and calcium signaling surges

A., Steinhilber, D., Sgambato, A., & Patrignani, P

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA- c) is a small peptide comprised of 16 amino acids, which is encoded by DNA not in the nucleus, but inside the mitochondrial genome, specifically inside the gene that encodes the mitochondrial 12S ribosomal RNA

These findings were confirmed by the analysis of the Delocalization Indices (D.I., Fig.2), which measure the average number of electron pairs delocalized (shared) between two atoms

Supports brain repair and resilience 26 under chronic stress

Protease-sensitive cleavable linkers use the dominant proteases found in tumor cell lysosomes for recognition and cleavage of a specific peptide sequence in the linker