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Intestinal changes were evaluated through 1) gut microbiota profiling and metabolite production (short-chain fatty acids (SCFAs), indoxyl sulfate), 2) structural and barrier integrity via histology, mucus staining, and tight junction markers (ZO-1, occludin, claudin-5), 3) mucosal immunity through M1/M2 macrophage profiling and Th17/Treg ratios, and 4) expression of inflammatory and oxidative stress markers

Consequently, researchers can examine multi-pathway mucosal repair without the logistical complexity of administering four separate compounds at individually timed intervals

2005;289:H1381H1390

10.1016/s0092-8674(03)00312-x Cell 68 LawJ

99,282 In small uncontrolled trials of limited duration, very-low-calorie, very-low-carbohydrate ketogenic, vegetarian, and vegan diets have each been shown to improve aspects of fibromyalgia, effects that did not appear to be fully explained by the weight loss alone

Acta oto-rhino-laryngologica belgica