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Histone marks with low stoichiometries could potentially play significant roles in locus-specific regulation, such as H3K4 trimethylation, while it is less plausible for low-level nonnuclear PTMs to have a significant impact, especially in context of inhibiting an enzymes function

These important findings led to the emergence of RNAi as a new type of RNA-based therapeutics

Koen et al., 2022)

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H&E of the tumorous tissue of the animal model treated with NP4 showed high amounts of cell death and nuclear fragmentation (Fig