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Begin with the lowest effective dose Observe response over 37 days Increase only if results plateau and no side effects are present In peptide therapy, conservative titration with consistent monitoring tends to yield better outcomes and fewer side effects than aggressive front-loading. Milekic, T

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[50] [53] The extracellular ligand-binding pocket is closed by a flexible "lid," and the intracellular region includes a short helix (H8) stabilized by -stacking interactions, both of which contribute to the receptor's dynamic conformational landscape

Previous animal studies have clearly shown a dose-dependent satiety effect of bupropion following intraperitoneal injection (52)