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Because the GST protein has a strong binding affinity for GSH, beads coated with the compound can be added to the protein mixture

M., Stetler, R

2015;10(6):e0129773

The intact-cell dependence of ML210 together with its lack of an obvious protein-reactive moiety led us to hypothesize that ML210 is a prodrug that undergoes chemical transformation in cells to covalently modify GPX4 via a novel electrophile